1675A Novel Murine Pneumonia and Bacteremia Model for Carbapenem-Resistant Klebsiella pneumoniae Infection
نویسندگان
چکیده
Resistant Klebsiella pneumoniae Infection Michael Kavanaugh, MD; Matthew Johnson, DVM; Paul Graf, PhD; Wesley Campbell, MD; Matthew Russell, MD; Lucy Betterton; Ramon Ayoade; Cara Pugliese DVM; Natalie Hall, PharmD; Brent House, PhD; Kejian Chen, MD, PhD; Ryan Maves, MD; Infectious Diseases, Naval Medical Center San Diego, San Diego, CA; CID, Naval Medical Center San Diego, San Diego, CA; Laboratory, Naval Medical Center San Diego, San Diego, CA; Internal Medicine, Naval Medical Center San Diego, San Diego, CA; Vivarium, Naval Medical Center San Diego, San Diego, CA; Special Operations Command, Camp Pendleton Marine Corps Base, Camp Pendleton, CA; Pharmacy, Naval Medical Center San Diego, San Diego, CA
منابع مشابه
Evaluation and Identification of Carbapenem Resistant Klebsiella pneumoniae Isolated from Hospitalized Patients in Qom City, (Iran)
Background and Objectives: Klebsiella pneumonia is a facultative anaerobe bacterium from enterobacteriaceae family, which causes a wide range of diseases, such as urinary tract infections, cystitis, pneumonia, surgical wounds infections, infectious endocarditis, and diffused infections, especially in patients with HIV infection and immunosuppression. The aim of this study was to identify carbap...
متن کاملDraft Genome Sequences of Three Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Isolates from Bacteremia
Hypervirulent Klebsiella pneumoniae strains have been increasingly reported worldwide, and there is emergence of carbapenem resistance among them. Here, we report the genome sequences of three carbapenem-resistant hypervirulent K. pneumoniae isolates isolated from bacteremic patients at a tertiary-care center in South India.
متن کاملEmergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenem- susceptible Klebsiella pneumoniae that carried mutant blaKPC-3. Meropenem was bactericidal against ceftazidime-avibactam- resistant K pneumoniae isolates in vitro. Nevertheless, the role of carbapenems in treating such infections remains uncertain, because meropenem resistance is...
متن کاملEstablishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different stra...
متن کاملDeaths Attributable to Carbapenem-Resistant Enterobacteriaceae Infections
We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively syn...
متن کامل